The Laboratory of Biomedical Flow Systems and Cell Engineering is actively involved in research focused on the development of microsystems for cell culture and analysis under microfluidic conditions.
The laboratory’s technological facilities enables comprehensive procedure for manufacturing microdevices with broad applications in cellular engineering and preclinical research. The scope of research work carried out in the laboratory concerns advanced two- and three-dimensional cell cultures: cell monolayers, aggregates, spheroids, multilayer and hydrogel systems, as well as cell cultures on nanofiber scaffolds.
Carried out research:
– tissues and organs modelling under microfluidic conditions (development of cancer-on-a-chip, organ-on-a-chip, body-on-a-chip microsystems);
– processes related to oncogenesis, metastasis and metabolism of cancer cells (including invasion and progression)
– differentiation of primary cells into other cell types;
– intercellular communication under physiological and pathological conditions.
The department includes:
– A technology laboratory equipped for designing, manufacturing, and modifying microfluidic system;
– A cell culture laboratory designed for the in vitro culture of mammalian cells, both normal and cancerous (BSL2);
– A cellular and molecular analysis laboratory, enabling work related to the isolation and analysis of genetic material (including the study of changes and mutations in gene expression) and research using flow cytometry (cell cycle analysis, type of cell death, immunophenotype assessment).
The Laboratory of Biomedical Flow Systems and Cell Engineering at CEZAMAT PW collaborates on research with numerous domestic institutions (such as Jagiellonian University, Warsaw University of Life Sciences, M. Nencki Institute of Experimental Biology of the Polish Academy of Sciences, National Institute of Medicines, Faculty of Chemistry of WUT) and international centers (EPFL), within the framework of several research projects funded by the National Science Center and as part of the internal Excellence Initiative – Research University program.