The Laboratory works on the development of new biomaterial technologies and solve the problems in the field of targeted therapy and implant and regenerative medicine. Our research is focused on synthesis and characterization of implantable materials and biocompatible/haemocompatible surfaces, as well as delivery systems for drugs and other active substances.
Our approach to obtaining materials for contact with living tissues is characterised by the use of processes running in aqueous solutions directly on the surface of the biomaterial with the maximum restriction of the organic solvents application.
A particularly important aspect of research conducted in the Laboratory includes the study of the interactions between biomaterials and cells or tissues, with emphasis on in vitro cytotoxicity tests. In addition, we analyze the physicochemical properties of biomaterials and their surfaces. Our team also analyses cell parameters using flow cytometry.
The works carried out include mainly:
- surface modification of polymers and metals in order to obtain materials with high biocompatibility,
- scaffolds and other polymer-metal structures for use as bone and cartilage implants,
- new inorganic-organic formulations having the ability to carry therapeutics based on selective targeting,
- modification of drug formulations in order to increase their bioavailability, biocompatibility and release time,
- in vitro cultures of mammalian cells,
- cytotoxicity tests: XTT, MTT, MTS, LDH, etc.
- evaluation of cell metabolism, differentiation, proliferation
- microscopic observations of cells and material surfaces: optical, fluorescence, confocal microscopy
- cell culture
- visualization of cells and assessment of their viability
- cytotoxicity tests according to ISO 10993-5